[June 11, 2009]

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Postdoctoral and PhD positions available in Egly lab at the IGBMC, Illkirch, France

Two postdoctoral and one PhD student positions are available immediately to investigate the role of the transcription/DNA repair factor TFIIH in the regulation of gene expression and genome maintenance. Mutations in three of the ten subunits of TFIIH results in genetic disorders xeroderma pigmentosum and trichothiodystrophy. Since several years, we have contributed to a better understanding of the regulation of protein coding gene transcription and nucleotide excision repair (NER) by dissecting the function of each of the ten subunits of TFIIH. In addition our work provide explanations for the clinical features of the XP/TTD/CS patients and those who have hormone deregulation problems.
1 - Research project on the interface of transcription and DNA repair. The study will focus on elucidating the phenotypical complexities in DNA repair deficient mouse models.
2 - Research project on the link between the basal transcription factor TFIIH and the nuclear receptors are available for a postdoc with experience in the transcription field. How their phosphorylation direct their steady state level ?
3 - Research project on post translational modifications of DNA repair factors and the study of new players in NER, (under the supervision of Dr. Frédéric Coin).
Specific studies include RT-PCR, ChIP, in vitro and in vivo transcription and DNA repair assays, establishment of stable cell lines, structure-function analyses.
Experience in molecular techniques and protein purification is desirable. Highly competitive salaries will be provided by the French National Research Agency and by the ERC (J-M Egly is a winner of the first 2008 ERC-advanced Grant Program).

Applicants should send a letter of interest, a full CV and the names and contact of three referees to:

Jean-Marc EGLY
Tel: 33 3 88 65 34 47

[June 7, 2009]

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Postdoctoral position available at the University of Nevada School of Medicine, Reno, NV, USA

NIH-funded postdoctoral position to study peripheral neuroeffector mechanisms.

We have recently determined that beta-nicotinamide adenine dinucleotide (NAD) is released along with norepinephrine and adenosine 5’-triphosphate during nerve stimulation in blood vessels and visceral smooth muscles from a large variety of species. NAD, not previously considered a player at the smooth muscle neuroeffector junction, appears to meet several criteria defining a neurotransmitter and a neuromodulator. The next logical step is to determine the functional correlates of this phenomenon in using models corresponding to physiological and pathological conditions in humans. We use neurochemistry, protein biochemistry, immunohistochemistry, functional and molecular biology techniques to study mechanisms of peripheral neurotransmission from transgenic animals to humans.

Funding is available for 5 years. Motivated individuals with excellent communication skills should submit curriculum vitae, brief description of research interests and experience, and the names and addresses of three references to:

Professor Violeta Mutafova-Yambolieva, M.D., Ph.D.
University of Nevada, Department of Physiology and Cell Biology
Anderson Medical Building/MS 352, Reno, NV 89557, USA
Phone: 775-784-6274

[June 4, 2009]

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Two postdoctoral / technician research positions at the Fox Chase Cancer Center, Philadelphia, USA

Researchers will study the molecular mechanisms of the chromatin remodeling and transcriptional activation using model organisms (Drosophila melanogaster and/or mouse) as well as in vitro assays.

Applicants should have a Ph.D. in molecular biology, molecular genetics, biochemistry, or a related field with 0-3 years postdoctoral research experience. Experience in confocal microscopy, live-cell imaging (FRAP, FRET) and genomics/proteomics would be helpful. The choice of the project will be discussed with a candidate during the interview.

Please send current CV and 3 letters of reference to:

Alexei Tulin, PhD
Epigenetics and Progenitor Cells Program
Fox Chase Cancer Center
333 Cottman Ave. R362,
Philadelphia, PA 19111, USA

[April 24, 2009]

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Postdoctoral and PhD positions in Cellular Signalling and Bioenergetics, University of Bergen, Norway

Research positions are available at the Department of Molecular Biology at the University of Bergen. The project is entitled "NAD kinase - Structure, Function and Regulation" and supported by the Research Council of Norway.

The main aims of the project include the identification of the roles of NADP and its synthesis in different subcellular compartments, the impact on signalling processes and the molecular mechanisms of their regulation. The studies are of particular relevance with regard to oxidative stress, development and tissue regeneration (see, for examples, JBC 282, 33562–33571, 2007, and the reviews Biochem. J. 402, 205-218, 2007 and TIBS 29, 111-118, 2004).

We are looking for excellent candidates with a strong background in molecular and cellular biology, enzymology and practical experience in one or more of the following areas: bioenergetics, cell biology, molecular biology, protein chemistry, analytical instrumentation, radioisotope techniques.

Salary for the postdoctoral position will be ~NOK 435,000 per year (about 48,000 Euros/year). The PhD stipend will be ~NOK 347,000 per year (about 38,500 Euros/year).

The PhD training will be connected to the MCB research school. Knowledge of the Norwegian language is not necessary, but good knowledge of English is required.

For more information please contact Professor Mathias Ziegler, Department of Molecular Biology, by phone +47 555 84591 or .

Applications should include a CV, copies of diplomas and transcripts, a list of publications and the names and contact details of at least two references.

Please note that two positions (for 3 years) are available at the moment (one PhD student, one post-doc). Deadline for applications is the 31st of March.

[March 4, 2009]

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