3- Animal and cellular models : the survival role of PARP-1 in mammals under genotoxic stress
• PARP-deficient cell lines established by random mutagenesis (open to contributions)
• PARP antisense strategies (open to contributions)
• Overexpression of full-length PARP-1 (open to contributions)
• Transdominant negative mutants (open to contributions)
• PARP-1 KO mice
• Double KO mice
4- Animal and cellular models : the role of PARP-1 in pathophysiological conditions
• Diabetes mellitus (open to contributions)
• Ischemia-reperfusion damage in brain, heart, kidney and bowel (open to contributions)
• Haemmorhagic shock (open to contributions)
• Septic shock (open to contributions)
• Tumorigenesis : PARP-1/p53 double KO
• The two-edged sword model for PARP-1 activation
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