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A Web resource on the PARP protein family and poly(ADP-ribosyl)ation
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Knockout mice for PARP and related genes (1)

PARP-1 gene disruption (exon 2)

DNA repair and maintenance of genomic stability under genomic stress Inflammatory injury
Hypersensibility to whole body gamma-radiation Pancreatic islet cells are resistant to the toxicity
of NO and ROI
Increased genomic instability (SCE, micronuclei) Protection against peroxynitrite-induced arthritis
Telomere length deregulation Protection against MPTP-induced Parkinsonism
p53 : low basal level, defective post damage Protection against streptozotocin-induced diabetes
Accumulation of DNA breaks following streptozotocin
treatment
Defective induction of NF-kappaB
Resistance to cerebral ischemia
Resistance to LPS-induced septic shock

References

Wang, Z.-Q. et al. (1995) Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

Wang, Z.-Q. et al. (1997) PARP is important for genomic stability but dispensable in apoptosis.






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